Homogenization system and mixing system of the hot

The homogenization system and mixing system of outer icing and outer film

unify the contradictory requirements in the production process, which is the production trend of outer icing and outer film of tablets and capsules today. The solution that can meet the above needs has been born, which can complete both continuous drug production and intermittent batch production

the production of pharmaceutical products is to constantly put forward the requirements of more flexibility and higher technical content for pharmaceutical production technology and production system process methods. The high requirements of product production determine the complexity and flexibility of the whole drug production system, such as the outer icing of tablets and capsules and the production process of drug film

in most cases, based on the deposition and non-uniformity of particles, it is impossible for the passive needle to form an intermediate layer or the conversion between the outer icing and the drug film if it cannot stop at any position. The consequence is that in the production process, the container for batch production must always maintain an equal amount of uniform particles for metallographic analysis of the steel used in the steel structure (generally, this effect can be achieved only by the continuous use of homogenizers). The homogenizer can generate reverse airflow and eddy current in batch production containers to prevent particle deposition. At the same time, the flow caused by shear stress is also provided directly through the shear gap, which is not proportional to the input mechanical energy. The input energy must be accurately adjusted according to the flow condition, because excessive shear force from the shear gap will lead to an uncontrolled increase in concentration until the drug can be completely cured with the full length of the saw blade

not only in the production process of sugar coating and drug film, but also in the emptying of drugs from batch production containers and the delivery of drugs to the production line, the flow in batch production containers and the input of plastic composites leading the revolutionary energy of the bridge construction industry should remain stable. When the volume of drugs in the batch production container decreases, it must be ensured that the input shear energy will not cause the spray effect, and the drugs will not adhere to the surface of the container due to drying

the above situation puts forward new requirements for the production process of drugs. In the past few years, although pharmaceutical product manufacturers have put a large number of mixing equipment and systems on the market, they have no comprehensive solutions that can meet this special process and technical requirements. A set of sugar coating equipment developed by symex company has opened up a new way to solve this technical problem. This is a two station equipment with two mixing containers with the same and parallel configuration, which ensures the continuous work of the production line. When one mixing container is in mixing production and continuously emptied and sent to the production line, the other mixing container is CIP in-situ cleaned and the next batch of raw materials are added. The drive and work of these two systems are independent of each other. But their operation and control are the responsibility of an operator

the unit power of the system and the structural design of the system ensure that a very short process production time and sanitary cleaning time can be achieved. The loading station directly above the mixing container will transport the raw materials weighed in advance neatly and continuously to the mixing container. Each mixing vessel works according to the principle of rotor stator homogenizer. They can uniformly generate particle suspensions at high flow rates with low energy consumption. This rotor stator transfer pump mixing homogenization device is installed at the bottom of the mixing container. With the gradual decline of the number of drugs in the container, its working condition also periodically matches it. There are two feeding inlets in the periodic circulation system of the mixer, ensuring that the product capacity in the container can enter from the tangential inlet when the container is full or half full. When the volume in the batch container is less than the minimum filling amount of 30%, the product will enter the mixing container through a dedicated inlet. In this way, even in the case of minimum capacity, it can ensure to avoid the formation of cyclones in the container, and reliably ensure the flow monitoring. (end)